A comparison of the histopathology of premalignant and malignant mammary gland lesions induced in sexually immature rats with those occurring in the human
M. Singh et al., A comparison of the histopathology of premalignant and malignant mammary gland lesions induced in sexually immature rats with those occurring in the human, LAB INV, 80(2), 2000, pp. 221-231
The injection of sexually immature female rats with 1-methyl-1-nitrosourea
results in a rapid induction of premalignant and malignant mammary gland le
sions within 35 days of carcinogen administration. This model affords the o
pportunity for investigators to study the process of mammary carcinogenesis
over a very short latency and to investigate early events in this process.
We have recently published on various aspects of this system including the
histology of the lesions induced, the time frame of their occurrence, and
their dependence on ovarian hormones for their maintenance and growth. In t
his report we present evidence that many aspects of the histopathology of m
ammary lesions in this model system are similar to those occurring in human
s. We also discuss aspects of the human disease, which are not recapitulate
d in this model.