Motion correction and lipid suppression for H-1 magnetic resonance spectroscopy

Spectral/spatial spin-echo pulses with asymmetric excitation profiles were incorporated into a PRESS-based localization sequence to provide lipid supp ression while retaining a sufficient amount of water to allow for correctio n of motion-induced shot-to-shot phase variations. H-1 magnetic resonance s pectroscopy data were acquired at 1.5 Tesla from a motion phantom and in vi vo from the human liver, kidney, and breast. The results demonstrated that lipids in the chemical shift stopband were completely suppressed and that f ull metabolite signal intensity was maintained after implementation of a re gularization algorithm based on phasing the residual water signal, Liver an d kidney spectra contained a large resonance at 3.2 ppm that was ascribed t o trimethylammonium moieties (betaine plus choline) and a weaker signal at 3.7 ppm that may result from glycogen. A breast spectrum from a histologica lly proven invasive ductal carcinoma displayed a highly elevated choline si gnal (3.2 ppm) relative to that from a normal volunteer. (C) 2000 Wiley-Lis s, Inc.