Transcriptional and post-transcriptional regulation of PTH gene expressionby vitamin D, calcium and phosphate

1,25(OH)(2)D-3 the biologically active metabolite of vitamin D is synthesiz ed in the renal proximal tubules from the hepatic metabolite 25 (OH)D, Lack of 1,25(OH)(2)D-3 is relevant to the pathogenesis of secondary hyperparath yroidism, and 1,25(OH)(2)D-3 itself is used effectively in the management o f renal failure patients to prevent secondary hyperparathyroidism. The scie ntific basis of this therapy is the finding that 1,25(OH)(2)D-3 potently de creases PTH gene transcription both in vitro and in vivo. Copyright (C) 200 0 S. Karger AG, Basel.