A. Sela-brown et al., Transcriptional and post-transcriptional regulation of PTH gene expressionby vitamin D, calcium and phosphate, MIN ELECT M, 25(4-6), 1999, pp. 342-344
1,25(OH)(2)D-3 the biologically active metabolite of vitamin D is synthesiz
ed in the renal proximal tubules from the hepatic metabolite 25 (OH)D, Lack
of 1,25(OH)(2)D-3 is relevant to the pathogenesis of secondary hyperparath
yroidism, and 1,25(OH)(2)D-3 itself is used effectively in the management o
f renal failure patients to prevent secondary hyperparathyroidism. The scie
ntific basis of this therapy is the finding that 1,25(OH)(2)D-3 potently de
creases PTH gene transcription both in vitro and in vivo. Copyright (C) 200
0 S. Karger AG, Basel.