Lithium induces morphological and functional differentiation in Neuro2a cells.

Authors
Rajadhyaksha, MS Jagtap, JC Kelkar, R Gokhale, PP Shastry, P
Citation
Ms. Rajadhyaksha et al., Lithium induces morphological and functional differentiation in Neuro2a cells., NEUROSC R C, 26(1), 2000, pp. 9-16
Citations number
21
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE RESEARCH COMMUNICATIONS
ISSN journal
08936609 → ACNP
Volume
26
Issue
1
Year of publication
2000
Pages
9 - 16
Database
ISI
SICI code
0893-6609(200001/02)26:1<9:LIMAFD>2.0.ZU;2-M
Abstract
Lithium is effectively used as a drug for bipolar disorders since decades a nd is also known to ba teratogenic in vertebrates. In the present study, we examined the effect of lithium on Neuro2a cells, lithium (2.5mM and 5mM) i nduced differentiation in Neuro2a cells as indicated by significantly highe r proportion of neurite bearing cells by 24h and enhanced activity of Acety lCholine Esterase (AChE) at 72h and 96h. treatment with lithium for 24h, ar rested the Neuro2a cells in G2/M phases of the cell cycle. Decreased prolif eration of cells was observed at 48h treatment of lithium. Our data demonst rates that lithium induces morphological and functional differentiation in Neuro2a cells.