A comprehensive study on the blockage of thyroid and gastric uptakes of Re-188-perrhenate in endovascular irradiation using liquid-tilled balloon to prevent restenosis

Re-188-perrhenate has been reported effective in preventing restenosis afte r percutaneous transluminal coronary angioplasty. However, if the balloon r uptures, Re-188-perrhenate is released into the circulation, causing high r adiation dosing to the thyroid and stomach. In this study, we evaluated the effects of perchlorate or iodide given at different times and in different ways for blocking the uptake of Re-188-perrhenate in the thyroid glands an d the stomach to find the best method to apply clinically to reduce the rad iation dose in case of balloon rupture. Sodium perchlorate, sodium iodide, or potassium iodide was given orally or intravenously to rats before, durin g, and after the injection of Re-188-perrhenate. The rats were sacrificed a nd we calculated the concentration of Re-188,perrhenate in various organs t o evaluate the preblocking, mixed formula, and postblocking effects of perc hlorate or iodide. Our data showed that the preblocking method effectively reduced the uptake of Re-188-perrhenate in both the thyroid and the stomach . The mixed formula method also demonstrated good blocking effect. The post blocking method showed obvious depression of thyroid uptake of perrhenate b ut its blocking effect on the stomach was not satisfactory. NUCL Men BIOL 2 7;1:83-87, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.