Tissue concentrations of endothelial cell adhesion molecules in the lower uterine segment during term parturition

Objective: To determine the concentration of endothelial cell adhesion mole cules in the lower uterine segment during parturition at term. Methods: We analyzed protein extracts from the lower uterine segments of 38 women who had nonelective cesareans at term. We measured concentrations of intercellular adhesion molecule-1, endothelial leukocyte adhesion molecule -1, vascular cell adhesion molecule-1, and platelet endothelial cell adhesi on molecule-1 by enzyme-linked immunosorbent assay. Subjects were grouped a ccording to cervical dilatation (less than 2 cm, n = 10; 2 to less than 4 c m, n = 9; 4-6 cm, n = 9; more than 6 cm, n = 10) and duration of labor (up to 6 hours, n = 14; 6-12 hours, n = 10; 12-24 hours, n = 9; longer than 24 hours, n = 5) at the time of cesarean. Results: The median concentration of intercellular adhesion molecule-1 incr eased significantly with increasing dilatation (from 2.24 ng/mg total prote in at less than 2 cm to 6.73 ng/mg at 4-6 cm) and increasing duration of la bor (from 2.53 ng/mg up to 6 hours to 5.90 ng/mg at 12-24 hours). However, this study did not have adequate statistical power to identify differences in concentrations of the other endothelial adhesion molecules. Conclusion: The results indicate that parturition at term is associated wit h expression of intercellular adhesion molecule-1. (Obstet Gynecol 2000;95: 363-6. (C) 2000 by The American College of Obstetricians and Gynecologists. ).