Outer-ring stereochemical modulation of cytotoxicity in cephalostatins

Authors
LaCour, TG Guo, CX Boyd, MR Fuchs, PL
Citation
Tg. Lacour et al., Outer-ring stereochemical modulation of cytotoxicity in cephalostatins, ORG LETT, 2(1), 2000, pp. 33-36
Citations number
23
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
1
Year of publication
2000
Pages
33 - 36
Database
ISI
SICI code
1523-7060(200001)2:1<33:OSMOCI>2.0.ZU;2-Y
Abstract
[GRAPHICS] 20- and 25'-epimers of cephalostatin 7, prepared by directed unsymmetrical pyrazine synthesis, address outer-ring topographical and stability question s and intimate an oxacarbenium ion rationale for the role in bioactivity of the spiroketal (E/F, E'/F') rings of this class of antitumor agents.