Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidants in aged rats

Authors
Arivazhagan, P Juliet, P Panneerselvam, C
Citation
P. Arivazhagan et al., Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidants in aged rats, PHARMAC RES, 41(3), 2000, pp. 299-303
Citations number
39
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMACOLOGICAL RESEARCH
ISSN journal
10436618 → ACNP
Volume
41
Issue
3
Year of publication
2000
Pages
299 - 303
Database
ISI
SICI code
1043-6618(200003)41:3<299:EODAOT>2.0.ZU;2-7
Abstract
The effect of DL-alpha-lipoic acid on lipid peroxidation and antioxidants s tatus has been studied in the blood of young and aged rats. Dr-alpha-lipoic acid, an antioxidant, was administered intraperitoneally for 7 and 14 days . Enzymatic and non-enzymatic antioxidant levels decreased with age but thi s decrease was attenuated by DL-alpha-lipoic acid. Lipid peroxide levels in creased with age, and were decreased by lipoic acid administration. These r esults suggest that biochemical lesions which are considered to be part of the normal ageing process are neutralized by DL-alpha-lipoic acid. (C) 2000 Academic Press.