Antihyperglycemic acetylenic glucosides from Bidens pilosa

Authors
Ubillas, RP Mendez, CD Jolad, SD Luo, J King, SR Carlson, TJ Fort, DM
Citation
Rp. Ubillas et al., Antihyperglycemic acetylenic glucosides from Bidens pilosa, PLANTA MED, 66(1), 2000, pp. 82-83
Citations number
13
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
66
Issue
1
Year of publication
2000
Pages
82 - 83
Database
ISI
SICI code
0032-0943(200002)66:1<82:AAGFBP>2.0.ZU;2-N
Abstract
In vivo bioassay-guided fractionation of the aqueous alcohol extract of the aerial parts of Bidens pilosa Sch. Bip. var. radiata (Asteraceae) using C5 7 BL/Ks-db/db mice as a model for type 2 diabetes, yielded two known polyac etylenic glucosides, identified as 2-beta-D-glucopyranosyloxy-1-hydroxy-5(E )-tridecene-7,9,11-triyne (1) and 3-beta-D-glucopyranosyloxy-1-hydroxy-6(E) -tetradecene-8,10,12-triyne (2). A 3:2 mixture of compounds 1 and 2 effecte d a significant drop in blood glucose.