BACKGROUND: Both the potential analgesic effects and side-effects of t
opical diclofenac sodium 0.1% are points of interest after excimer las
er phototherapeutic keratectomy. METHODS: Excimer laser phototherapeut
ic keratectomy was performed in 134 eyes of 134 patients. In 65 eyes (
65 patients), the effects of topical diclofenac given three times a da
y for 3 to 4 days were compared to a control group of 69 eyes (69 pati
ents). All patients received paracetamol for systemic analgesia and we
re patched after surgery until reepithelialization. RESULTS: Twenty-ei
ght patients (43%) of the diclofenac group needed additional systemic
analgesics compared to 67 patients (95%) in the control group. Seventy
-two hours after surgery we found no significant differences in cornea
l epithelial wound healing and no severe complications. CONCLUSION: To
pical diclofenac sodium reduces postoperative pain in patients after p
hototherapeutic keratectomy.