Genomic changes and HPV type in cervical carcinoma

To identify chromosomal regions that may include the loci of abnormally exp ressed cellular genes and may be specifically altered depending on the hist ological subtype of the tumor, we studied primary cervical carcinoma using CGH and HPV genotyping. Eighty-seven percent of the primary tumors were pos itive for DNA of a "high-risk" HPV type (e.g., 16 or 18). In the cervical c arcinomas, without reference to histologic subtype, overrepresentation of c hromosome 3q was the most consistent chromosomal aberration with underrepre sentation of chromosome 3p also a frequent finding, Chromosome arms Iq, 5p, 20q, and Xq were overrepresented in many tumors and 3p loss and 5p, 8q, an d 16q gain were only associated with squamous cell carcinoma in this series .