Yl. Ge et al., Brain atrophy in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis: Longitudinal quantitative analysis, RADIOLOGY, 214(3), 2000, pp. 665-670
Citations number
39
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
PURPOSE: To determine annual rates of volumetric changes in the whole-brain
parenchyma of patients with relapsing-remitting and secondary progressive
multiple sclerosis (MS) and test the hypothesis that these changes correlat
e with clinical disability.
MATERIALS AND METHODS: A computer-assisted segmentation technique with thin
-section magnetic resonance (MR) imaging was used in 36 patients with MS (2
7 relapsing-remitting, nine secondary progressive) and in 20 control subjec
ts to quantify brain and cerebrospinal fluid volumes. To determine the degr
ee of brain atrophy, the percentage brain parenchyma volume (PBV) relative
to that of intracranial contents was calculated.
RESULTS: At the beginning of the study, the PBV was smaller in the MS group
than in the control group (P = .007); brain parenchyma volumes were simila
r. The median rate of brain volume loss was 17.3 mL per year in patients wi
th relapsing-remitting MS and 23.6 mL per year in those with secondary prog
ressive MS. There was a negative correlation between brain atrophy and Expa
nded Disability Status Scale (EDSS) score in patients with secondary progre
ssive MS (r = -0.69, P = .004) and no correlation in patients with relapsin
g-remitting MS. T2 lesion volume did not correlate with brain atrophy in ei
ther group.
CONCLUSION: The correlation between brain atrophy and EDSS score was better
in patients with secondary progressive MS than in those with relapsing-rem
itting MS.