SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF NITROXANTHONES - 1ST COMMUNICATION - SYNTHESIS AND DIFFERENTIAL SCANNING CALORIMETRY ANALYSIS

Authors
IBROM WGA FRAHM AW
Citation
Wga. Ibrom et Aw. Frahm, SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF NITROXANTHONES - 1ST COMMUNICATION - SYNTHESIS AND DIFFERENTIAL SCANNING CALORIMETRY ANALYSIS, Arzneimittel-Forschung, 47(5), 1997, pp. 662-667
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
47
Issue
5
Year of publication
1997
Pages
662 - 667
Database
ISI
SICI code
0004-4172(1997)47:5<662:SAAAON>2.0.ZU;2-E
Abstract
The syntheses of mono-, di-, tri- and tetranitroxanthones via intramol ecular Friedel-Crafts acylation of nitrated 2-phenoxybenzoic acids as well as via selective stepwise nitration of xanthone and the nitroxant hones gained from the first route are described. The synthesized nitro xanthones investigated by DSC (differential scanning calorimetry) anal ysis show a surprisingly high thermodynamic stability which was confir med by quantum chemical calculations.