Provincial distribution of three HIV-1 resistant polymorphisms (CCR5-Delta32, CCR2-64I, and SDF1-3 ' A) in China

Authors
Xiao, JH Hu, F Xu, HY Su, B Jiang, YM Luo, JC Zhang, WL Tan, JZ Jin, L Lu, DR
Citation
Jh. Xiao et al., Provincial distribution of three HIV-1 resistant polymorphisms (CCR5-Delta32, CCR2-64I, and SDF1-3 ' A) in China, SCI CHINA C, 43(1), 2000, pp. 16-20
Citations number
9
Categorie Soggetti
Experimental Biology
Journal title
SCIENCE IN CHINA SERIES C-LIFE SCIENCES
ISSN journal
10069305 → ACNP
Volume
43
Issue
1
Year of publication
2000
Pages
16 - 20
Database
ISI
SICI code
1006-9305(200002)43:1<16:PDOTHR>2.0.ZU;2-B
Abstract
CCR5- Delta 32, CCR2-641, mutants in two chemokine receptors and SDF1-3' A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinc es (cities) in China. No CCR5- Delta 32 was observed. CCR2-641 and SDF1-3' A had reverse distribution dine from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. I mportant information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.