Kinetics of plasma and tissue distribution of 9-cis-retinoic acid in rat

The biotransformation and tissue distribution of 9-cis-retinoic acid was in vestigated in hairless rats, Indeed, only limited information is available about the pharmacokinetics of 9-cis-retinoic acid. Assuming that the target site for retinoids is the skin, tissue distribution study is therefore par ticularly justified. Following single oral administration of 30 mg/kg of 9- cis-retinoic acid, the parent drug and five metabolites were detected in pl asma, Additionally, concentrations of 9-cis-retinoic acid and metabolites w ere determined in the skin and seven other tissues. The distribution of 9-c is-retinoic acid was rapid in all of the organs studied (T-max less than or equal to 2 h). In skin, unchanged 9-cis-retinoic acid was still measurable up to 168 h after administration and was undetectable in other organs and plasma after 48 h. Copyright (C) 2000 S, Karger AG, Basel.