Citation
D. Behnke et al., Forskolin studies, TETRAHEDRON, 56(8), 2000, pp. 1081-1095
Citations number
43
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020
→ ACNP
Volume
56
Issue
8
Year of publication
2000
Pages
1081 - 1095
Database
ISI
SICI code
0040-4020(20000218)56:8<1081:FS>2.0.ZU;2-0
Abstract
A new nucleophilic isoprenoid C-5 reagent is introduced which allowed synth
esis of an advanced and optically active forskolin intermediate in a very e
fficient way. In addition, docking experiments that are based on X-ray resu
lts indicate that there might exist forskolin analogues with improved prope
rties as far as binding to adenylyl cyclases and synthetic accessibility ar
e concerned. (C) 2000 Elsevier Science Ltd. All rights reserved.