Efficient synthesis of 1-heterocyclic-3-aminopyrrolidinones

Authors
Bell, IM Beshore, DC Gallicchio, SN Williams, TM
Citation
Im. Bell et al., Efficient synthesis of 1-heterocyclic-3-aminopyrrolidinones, TETRAHEDR L, 41(8), 2000, pp. 1141-1145
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
8
Year of publication
2000
Pages
1141 - 1145
Database
ISI
SICI code
0040-4039(20000219)41:8<1141:ESO1>2.0.ZU;2-9
Abstract
A novel two-step synthesis of optically active 3-aminopyrrolidinones is des cribed. The route allows access to pyrrolidinones with heterocyclic functio nality that is incompatible with known methodology, and affords the final p roducts in good to excellent yield and high enantiomeric purity. The Mitsun obu cyclodehydration is shown to be an efficient method for the formation o f a variety of gamma-lactams. (C) 2000 Published by Elsevier Science Ltd. A ll rights reserved.