The synthesis of unsymmetrical S-1-(3 '-O-thymidine-O-methanephosphonyl)-S-2-p-nitrophenyl disulfides and their reactions with triphenylphosphine

Authors
Chworos, A Wozniak, LA Stec, WJ
Citation
A. Chworos et al., The synthesis of unsymmetrical S-1-(3 '-O-thymidine-O-methanephosphonyl)-S-2-p-nitrophenyl disulfides and their reactions with triphenylphosphine, TETRAHEDR L, 41(8), 2000, pp. 1219-1222
Citations number
6
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
8
Year of publication
2000
Pages
1219 - 1222
Database
ISI
SICI code
0040-4039(20000219)41:8<1219:TSOUS'>2.0.ZU;2-R
Abstract
The reaction of thymidine 3'-methanephosphonothioic acid with p-nitrophenyl sulfenyl chloride provides S-1 -(3'-O-thymidine-O-methanephosphonyl)-S-2-p- nitrophenyl disulfide which, in the presence of an excess of sulfenyl chlor ide and triphenylphosphine gives, in a stereospecific manner, thymidine 3'- (S-p-nitrophenyl methanephosphonodithioate). (C) 2000 Elsevier Science Ltd. All rights reserved.