Efficacy of bothropic antivenom and its IgG(T) fraction in restoring fibrinogen levels of Bothrops jararaca envenomed mice

Authors
Fernandes, I Tavares, FL Sano-Martins, I Takehara, HA
Citation
I. Fernandes et al., Efficacy of bothropic antivenom and its IgG(T) fraction in restoring fibrinogen levels of Bothrops jararaca envenomed mice, TOXICON, 38(7), 2000, pp. 995-998
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
TOXICON
ISSN journal
00410101 → ACNP
Volume
38
Issue
7
Year of publication
2000
Pages
995 - 998
Database
ISI
SICI code
0041-0101(200007)38:7<995:EOBAAI>2.0.ZU;2-#
Abstract
Bothropic antivenom and its IgG(T) fraction, administered 4 h after experim ental envenoming by Bothrops jararaca in Swiss mice, were compared for thei r abilities to restore fibrinogen 24 or 48 h after treatment. IgG(T) was ab le to normalise fibrinogen levels as efficiently as conventional antivenom. As IgG(T) also neutralises most anti-toxic activities of Bothrops venom, o ur results suggest that IgG(T) could be a better alternative treatment for envenoming due to the reduced amount of extraneous proteins, which may faci litate the induction of early adverse reactions. (C) 2000 Elsevier Science Ltd. All rights reserved.