Finding the genes that direct mammalian development - ENU mutagenesis in the mouse

Authors
Anderson, KV
Citation
Kv. Anderson, Finding the genes that direct mammalian development - ENU mutagenesis in the mouse, TRENDS GEN, 16(3), 2000, pp. 99-102
Citations number
31
Categorie Soggetti
Molecular Biology & Genetics
Journal title
TRENDS IN GENETICS
ISSN journal
01689525 → ACNP
Volume
16
Issue
3
Year of publication
2000
Pages
99 - 102
Database
ISI
SICI code
0168-9525(200003)16:3<99:FTGTDM>2.0.ZU;2-8
Abstract
The genetic control of mammalian embryogenesis is not well understood. N-et hyl-N-nitrosourea (ENU) mutagenesis screens in the mouse provide a route to identify more of the genes that are required for mammalian development. Th e characterization of ENU-induced mutations can build on the resources prov ided by the mouse and human genome projects to help define the tissue inter actions and signaling pathways that direct early mammalian development.