ISOLATION AND CHARACTERIZATION OF NEW CHLAMYDOSPOROL RELATED METABOLITES OF FUSARIUM-CHLAMYDOSPORUM AND FUSARIUM-TRICINCTUM

Fusarium chlamydosporum strain T-826 isolated from corn in the USA pro duced chlamydosporol and two analogs which have been identified by var ious spectroscopic techniques as: 7,8-dihydro-5 -trans-7,8-dimethyl-2H ,5H-pyrano(4,3-b)pyran-2-one (or isochlamydosporol) and 4-methoxy-5-hy droxymethyl-6-(3-butan-2-ol)-2H-one (or chlamydospordiol). Chlamydospo rol (compound a + b) chlamydospordiol (compound c) and isochlamydospor ol (compound d) were produced together (up to 6000 mu g/g) by 3 out of 11 isolates of F. chlamydoporum and by 3 out of 24 isolates of F. tri cinctum from various substrates and geographic origin. Three isolates of F. chlamydosporum and one isolate of F. tricinctum produced only ch lamydospordiol and 2, isolates of F. tricinctum produced chlamydosporo l (a + b), and chlamydospordiol (c).