Cardiac procedures are performed less frequently in Canada than in the Unit
ed States (US), yet rates of cardiac death and myocardial infarction are si
milar, We therefore sought to compare long-term symptoms find quality of li
fe in Canadian and American patients undergoing initial coronary revascular
ization, The 161 patients enrolled in the Bypass Angioplasty Revascularizat
ion Investigation at the Montreal Heart institute were compared with 934 pa
tients enrolled at 7 US sites. patients' outcomes were documented far 5 yea
rs after random assignment to percutaneous transluminal coronary angioplast
y or coronary artery bypass graft surgery. Functional status was assessed u
sing the Duke Activity Status index. Canadian patients were significantly y
ounger and had more angina at study entry. Death and nonfatal myocardial in
farction were not significantly different between Canadian and US patients
after adjustment for baseline risk. Canadian patients had significantly gre
eter improvements in functional status at 1-year follow-up (Duke Activity S
tatus Index score + 13.5 vs + 6.0, p = 0.002), but this difference progress
ively narrowed over 5 years. Angina was equally prevalent in Canadian and U
S patients at 1 year (16% vs 19%), but significantly more prevalent in Cana
dian patients at 5 years (36% vs 16%, p = 0.001), Repeat revascularization
procedures were performed less often over 5 years among Canadian patients (
26% vs 34%, p = 0.08), especially coronary artery bypass graft surgery afte
r initial percutaneous transluminal coronary angioplasty (18% vs 32%, p = 0
.03). These results suggest more anginal symptoms are required in Canada be
fore coronary revascularization, but as a result Canadians receive greater
improvements in quality of life after the procedure. (C)2000 by Excerpta Me
dica, Inc.