Chondromyxoid fibromas are uncommon tumors most often seen in long bones of
adolescent and young males. Involvement of craniofacial bones is extremely
unusual, with sporadic case reports described in the literature. I-lie des
cribe the first case of chondromyxoid fibroma arising in the nasal septum w
ith local destruction and expansile growth into the ethmoid bone and inferi
or turbinate in a 60-year-old female. The fortuitous discovery of this othe
rwise asymptomatic lesion and its follow-up are detailed The literature is
reviewed and salient clinical, radiographic, and pathologic correlative fin
dings are emphasized.