Detection of coronary artery disease by iodine-123-labeled iodophenyl-9-methyl pentadecanoic acid SPECT: Comparison with thallium-201 and iodine-123 BMIPP SPECT
K. Fukuchi et al., Detection of coronary artery disease by iodine-123-labeled iodophenyl-9-methyl pentadecanoic acid SPECT: Comparison with thallium-201 and iodine-123 BMIPP SPECT, ANN NUCL M, 14(1), 2000, pp. 11-16
To evaluate the ability to detect coronary artery disease (CAD) with a new
iodine-123 labeled branched fatty acid analog, iodophenyl-9-methyl pentadec
anoic acid (9MPA), we performed 9MPA, iodine-123 BMIPP and thallium-201 SPE
CT in patients with CAD. Twenty-four patients (11 with effort angina and 13
with myocardial infarction) were studied. In all patients, 9MPA SPECT was
obtained at 15 min after injection. Twenty-three patients underwent stress-
redistribution Tl-201 SPECT and 9 patients also underwent BMIPP myocardial
fatty acid imaging. The regional uptakes of 9MPA, BMIPP and Tl-201 were sco
red semiquantitatively and the segmental agreements were compared among the
m. In the segment-to-segment comparison, 9MPA showed reduced activity in co
mparison to stress-redistribution Tl-201 imaging. The defect score of 9MPA
was significantly greater than that of redistribution Tl-201 images (p < 0.
001). In addition, segmental 9MPA uptake was lower than BMIPP and its defec
t score was significantly greater than that of BMIPP (p < 0.05). When coron
ary angiography was used as the criterion, 9MPA showed higher sensitivity a
nd lower specificity than stress-redistribution Tl-201 (p < 0.01). In concl
usion, fatty acid metabolic imaging with 9MPA is a sensitive but nonspecifi
c detector of CAD.