The clinical presentation of menopause can resemble the symptoms of a mood
disorder. We describe the case of a 31-yr-old student helicopter pilot who
presented to the Aviation Psychiatry Department with a several-month histor
y of inconsistent training performance, mood lability, tearfulness, anxiety
, insomnia, fatigue, and decreased concentration. Symptoms persisted despit
e stress management training and resolution of family stressors, and furthe
r evaluation revealed other symptoms consistent with early menopause. Sympt
oms responded to estrogen/progesterone therapy, and patient returned to fli
ght training. The clinical presentation, differential diagnosis, treatment,
and aeromedical disposition of perimenopause and menopause are discussed.