Anticipatory errors after unilateral lesions of the subthalamic nucleus inthe rat: Evidence for a failure of response inhibition

Citation
Jm. Phillips et Vj. Brown, Anticipatory errors after unilateral lesions of the subthalamic nucleus inthe rat: Evidence for a failure of response inhibition, BEHAV NEURO, 114(1), 2000, pp. 150-157
Citations number
20
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BEHAVIORAL NEUROSCIENCE
ISSN journal
07357044 → ACNP
Volume
114
Issue
1
Year of publication
2000
Pages
150 - 157
Database
ISI
SICI code
0735-7044(200002)114:1<150:AEAULO>2.0.ZU;2-4
Abstract
The nature of anticipatory responding in rats with unilateral subthalamic n ucleus lesions was examined. Rats were trained to respond toward visual tar gets that were preceded by 1 of 4 different cues. For normal rats, a cue in vokes an involuntary attentional orienting that enhances processing of the target at the location of attention. The cue is also a salient stimulus to which a response must be suppressed. Therefore, this task was used to inves tigate possible attentional impairments, as well as the ability of a lesion ed rat to suppress competing motor programs. Responding under target contro l was not affected by the lesion. Then was an increase in anticipatory resp onses before target onset, which could be accounted for by a failure to inh ibit contralateral responses.