Structural conservation and variation among U5 small nuclear RNAs from trypanosomatid protozoa

Authors
Schnare, MN Gray, MW
Citation
Mn. Schnare et Mw. Gray, Structural conservation and variation among U5 small nuclear RNAs from trypanosomatid protozoa, BBA-GENE ST, 1490(3), 2000, pp. 362-366
Citations number
32
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
ISSN journal
01674781 → ACNP
Volume
1490
Issue
3
Year of publication
2000
Pages
362 - 366
Database
ISI
SICI code
0167-4781(20000229)1490:3<362:SCAVAU>2.0.ZU;2-Y
Abstract
U5 snRNAs in trypanosomatid protozoa do not contain the trimethylguanosine cap structures that are often targeted in snRNA isolation procedures. As a result, the trypanosomatids are not well represented in the database of ava ilable U5 snRNA sequences. We have isolated and determined the sequence of the U5 snRNA from Crithidia fasciculata. Comparison with previously publish ed trypanosomatid U5 snRNA sequences allows us to deduce the pattern of str uctural conservation and variation among these very divergent snRNA molecul es. (C) 2000 Elsevier Science B.V. All rights reserved.