Protein kinase C binding partners

Members of the protein kinase C family respond tio second messengers and ar e involved in controlling a broad array of cellular functions. The overlapp ing specificity and promiscuity of these proteins has promoted the view tha t specific binding proteins constrain individual family members to create t he appropriate specificity of action. It is speculated that such protein ki nase C-regulator protein interactions affect substrate availability as well as exposure to allosteric activator(s) and that consequent interactions sp ecify cellular location and impose integration with other signaling systems . These predicted features have been realized in the identification of many protein kinase C interacting proteins and examples of these are discussed. (C) 2000 John Wiley & Sons, Inc.