Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

Authors
de Wilt, JHW ten Hagen, TLM de Boeck, G van Tiel, ST de Bruijn, EA Eggermont, AMM
Citation
Jhw. De Wilt et al., Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion, BR J CANC, 82(5), 2000, pp. 1000-1003
Citations number
25
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
82
Issue
5
Year of publication
2000
Pages
1000 - 1003
Database
ISI
SICI code
0007-0920(200003)82:5<1000:TNFAIM>2.0.ZU;2-I
Abstract
Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-alpha) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increa se in melphalan tumour tissue concentration after ILP when TNF-alpha was ad ded to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-alpha in ILP. (C) 2000 Cancer Research Campaign.