Prevalence of the APC E1317Q variant in colorectal cancer patients

The notion that some common variants of APC might confer an increased color ectal tumour risk is supported by studies of the I1307K polymorphism. Recen tly it has been proposed that the E1317Q variant is also associated with an increased risk. We have studied the prevalence of E1317Q in 364 colorectal cancer patients and in 290 controls. Two patients were shown to possess E1 317Q. Neither had a family history of colorectal cancer or co-existent aden omatous polyps. Two controls also carried E1317Q. This finding suggests tha t E1317Q is unlikely to be associated with anything more than a moderate in crease in risk of colorectal cancer. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.