DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells

Citation
Tbh. Geijtenbeek et al., DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells, CELL, 100(5), 2000, pp. 587-597
Citations number
37
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELL
ISSN journal
00928674 → ACNP
Volume
100
Issue
5
Year of publication
2000
Pages
587 - 597
Database
ISI
SICI code
0092-8674(20000303)100:5<587:DADCHP>2.0.ZU;2-E
Abstract
Dendritic cells (DC) capture microorganisms that enter peripheral mucosal t issues and then migrate to secondary lymphoid organs, where they present th ese in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and bin ds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its tr ansport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.