Radical cyclization reaction using a combination of phosphinic acid and a base in aqueous ethanol

Authors
Yorimitsu, H Shinokubo, H Oshima, K
Citation
H. Yorimitsu et al., Radical cyclization reaction using a combination of phosphinic acid and a base in aqueous ethanol, CHEM LETT, (2), 2000, pp. 104-105
Citations number
13
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
2
Year of publication
2000
Pages
104 - 105
Database
ISI
SICI code
0366-7022(20000205):2<104:RCRUAC>2.0.ZU;2-6
Abstract
Treatment of allylic ether of 2-iodophenol or 2-haloethanal allylic acetal with phosphinic acid, a base and a radical initiator (AIBN or triethylboran e) in aqueous ethanol provided the corresponding radical cyclization produc t in excellent yield. An addition of a base is critical to employ phosphini c acid as a radical mediator.