Enhancement of diastereomer selectivity using highly-oriented polymer stationary phase

Enantiomer separation has been often realized with reversed phase liquid ch romatography using diastereomerizing reagents with simply-hydrophobized sil ica. The present study demonstrates that diastereomer selectivity can be en hanced through highly-oriented organic phase produced by achiral poly(octad ecyl acrylate)-grafted on silica and a carbonyl-pi interaction due to the a crylate moiety is effective as the driving force for the selectivity enhanc ement.