Adequate levofloxacin treatment schedules for uterine cervicitis caused byChlamydia trachomatis

The in vivo efficacy of levofloxacin (LVFX), one of the most standard new q uinolone antimicrobial agents, in the different treatment schedules of Chla mydia trachomatis uterine cervicitis in women was evaluated. Cervical C. tr achomatis was detected by polymerase chain reaction. LVFX at a dosage of 30 0 mg t.i.d. for 5, 7 and 14 days was orally administered to 18, 33 and 35 J apanese patients, respectively. The eradication rate and the recurrence rat e in the different treatment schedules of C. trachomatis were evaluated. Th e eradication rate in 5-, 7- or 14-day cases was 44.4, 87.9 or 88.6%, respe ctively. The recurrence rate of 5-, 7- or 14-day cases was 50.0, 0 or 0%, r espectively. Seven-day treatment with LVFX is adequate for and effective in C. trachomatis uterine cervicitis. Copyright (C) 2000 S.Karger AG, Basel.