CHROMOSOMAL FINDINGS IN 150 COUPLES REFERRED FOR GENETIC-COUNSELING PRIOR TO INTRACYTOPLASMIC SPERM INJECTION

A total of 150 infertile couples underwent chromosome analysis and gen etic counselling before intracytoplasmic sperm injection (ICSI), Chrom osomal abnormalities, including low-level sex chromosome mosaicism, we re detected in 12% of the men and an unexpectedly high 6% of the women , Chromosomal abnormalities included gonosomal mosaicism in 13 eases, Robertsonian translocations in four males, autosomal reciprocal transl ocations in five cases, reciprocal translocation involving a sex chrom osome in one case, inversions in three cases and a marker chromosome i n one male, Chromosomal variants found in 11 women and 13 men were not included in the above percentages, Couples with a chromosomal aberrat ion in one partner received a second counselling, The different aspect s of genetic counselling in these couples are discussed, In conclusion , we recommend genetic counselling and chromosomal analysis of men and women prior to ICSI therapy.