Chloroxylenol and zinc oxide containing cream (Nels cream (R)) vs. 5% benzoyl peroxide cream in the treatment of acne vulgaris. A double-blind, randomized, controlled trial
Pp. Papageorgiou et Ac. Chu, Chloroxylenol and zinc oxide containing cream (Nels cream (R)) vs. 5% benzoyl peroxide cream in the treatment of acne vulgaris. A double-blind, randomized, controlled trial, CLIN EXP D, 25(1), 2000, pp. 16-20
Forty-one subjects completed a double-blind controlled randomized study com
paring the following: (i) Nels cream(R) (containing chloroxylenol and zinc
oxide); (ii) 5% benzoyl peroxide cream; and (iii) the vehicle of the Nels c
ream. Patients applied the medications twice daily for 8 weeks. At the end
of the test period there was no significant difference in the reduction of
inflammatory and noninflammatory lesion counts achieved by Nels cream and b
enzoyl peroxide. Both creams proved superior to the vehicle. Efficacy gradi
ng by subjects and investigators showed no significant difference between N
els cream and benzoyl peroxide. However, side-effects such as peeling and d
ryness caused by the treatment were significantly less in the Nels cream gr
oup.