FIRST-TRIMESTER REPEATED ABORTION IS NOT ASSOCIATED WITH ACTIVATED PROTEIN-C RESISTANCE

The present study was undertaken to investigate the possible associati on between activated protein C resistance and first-trimester repeated abortion, Fifty-five consecutive patients with unexplained first-trim ester repeated abortion and 50 healthy control women having at least o ne child but no previous abortion were included, Activated protein C r esistance was measured in all subjects and factor V Leiden genotype te sting was performed in those individuals with phenotypic activated pro tein C resistance, One patient with first-trimester repeated abortion and one control subject had phenotypic activated protein C resistance, Genotype analysis confirmed that both subjects were heterozygous for factor V Leiden, Our results indicate that first-trimester repeated ab ortion is not associated with activated protein C resistance, Factor V Leiden screening in first-trimester repeated abortion is not warrante d.