Transcriptional mechanisms in the development of motor control

Considerable progress has been made in understanding how combinatorially ex pressed transcription factors control the development of neuronal subtypes in the fly and vertebrate central nervous systems. The mode of action of ma ny of these factors has been conserved from invertebrates to vertebrates th roughout evolution, such as the formation and regulation of specific transc riptional complexes, the utilization of repressors for maintaining specific ity, and the use of phosphorylation as an important means for transiently a ltering transcriptional activity.