There has been growing interest in the possibility of screening for ovarian
cancer. This article addresses papers published following a systematic rev
iew of all prospective ovarian cancer screening studies since 1998. In the
past year, new markers have been reported and previous strategies have been
refined. A randomized controlled trial of ovarian cancer screening has sho
wn a survival benefit in women who developed ovarian cancer in the screened
group. Although the results do not justify ovarian cancer screenmg in the
general population, the data support the need for a larger randomized trial
powered to assess the impact of screening on mortality. (C) 2000 Lippincot
t Williams & Wilkins.