Immunological similarities between primary sclerosing cholangitis and chronic sclerosing sialadenitis - Report of the overlapping of these two autoimmune diseases
K. Tsuneyama et al., Immunological similarities between primary sclerosing cholangitis and chronic sclerosing sialadenitis - Report of the overlapping of these two autoimmune diseases, DIG DIS SCI, 45(2), 2000, pp. 366-372
Primary sclerosing cholangitis (PSC) is characterized by destructive inflam
mation and fibrosis affecting the bile duels. The etiology of PSC is still
unknown, although lymphocytic infiltration in the portal areas suggests an
immune-mediated destruction of the bile ducts. Patients with one autoimmune
disease often suffer from one or more other autoimmune diseases, it is wel
l known that there is a close relationship between PSC and inflammatory tro
wel disease, particularly ulcerative colitis(UC). However, the pathological
findings in UC and other overlap diseases do not resemble those of PSC. In
the present study, we report a patient with chronic sclerosing sialadeniti
s (Kuttner's tumor) and PSC. It is compared the sclerosing changes in both
salivary glands and bile ducts histologically. In addition, the expression
pattern of mast cell tryptase, b-FGF, and HLA-DR were examined in both tiss
ues immunohistochemically. Histological features of sclerosing change in bo
th salivary and bile ducts were quite similar. Marked mast cell infiltratio
n and b-FGF expression were seen in the sclerosing areas in both tissues. I
n active inflammatory areas of the salivary glands, HLA-DR expression was a
lso seen. We hypothesized that similar immune reactions occur in both the s
alivary gland and bile ducts and are responsible for the fibrosis that foll
ows.