Integrated bacterial genomics for the discovery of novel antimicrobials

Authors
Loferer, H Jacobi, A Posch, A Gauss, C Meier-Ewert, S Seizinger, B
Citation
H. Loferer et al., Integrated bacterial genomics for the discovery of novel antimicrobials, DRUG DISC T, 5(3), 2000, pp. 107-114
Citations number
36
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DISCOVERY TODAY
ISSN journal
13596446 → ACNP
Volume
5
Issue
3
Year of publication
2000
Pages
107 - 114
Database
ISI
SICI code
1359-6446(200003)5:3<107:IBGFTD>2.0.ZU;2-E
Abstract
Sequencing of bacterial genomes has been progressing with breathtaking spee d. Currently, the genomes of 23 bacterial species are sequenced, with appro ximately 40 more sequencing projects in progress. Industrial research is no w facing the challenge of translating this information efficiently into dru g discovery. This review will summarize the impact of bacterial genomics, b ioinformatics and second-generation genomic technologies on target identifi cation, assay development, lead optimization and compound characterization.