A CASE OF ROBINOW-SYNDROME ACCOMPANIED BY PARTIAL GROWTH-HORMONE INSUFFICIENCY TREATED WITH GROWTH-HORMONE

We report on a 10-year-old Japanese girl with Robinow syndrome accompa nied by partial growth hormone (GH) insufficiency. We started GH repla cement therapy at the chronological age of 6.5 years. In this case, im provement in the growth velocity was remarkable, but bone maturation a ccelerated even more. In order to avoid further acceleration of bone m aturation, we started to treat our patient at the chronological age of 9.8 years with GH combined with gonadal suppression therapy using a l uteinizing hormone releasing hormone analogue. However, no improvement in height SDS for bone age was attained. Our observations suggest tha t the indication of GH therapy for patients with Robinow syndrome need s careful consideration.