Stabilization of carbenium ions derived from ethynylestradiol by differentadjacent organometallic moieties. Implication in the inactivation of the estrogen receptor

Authors
Osella, D Ravera, M Nervi, C Cavigiolio, G Vincenti, M Vessieres, A Jaouen, G
Citation
D. Osella et al., Stabilization of carbenium ions derived from ethynylestradiol by differentadjacent organometallic moieties. Implication in the inactivation of the estrogen receptor, EUR J INORG, (3), 2000, pp. 491-497
Citations number
38
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
ISSN journal
14341948 → ACNP
Issue
3
Year of publication
2000
Pages
491 - 497
Database
ISI
SICI code
1434-1948(200003):3<491:SOCIDF>2.0.ZU;2-V
Abstract
The stabilization of carbenium ions by an adjacent organotransition metal m oiety has been evaluated using the classical Deno's method as well as a new procedure based on DCI-MS spectrometry. The ability of transition metal cl usters to enhance the stability of a proximate carbocationic center in 17 a lpha-alkynylestradiol-[OM] derivatives {[OM] = Co-2(CO)(6); Co-2(CO)(4)(dpp m); Mo2Cp2(CO)(4); M-3(CO)(10), M = Ru, Os; HRu3(CO)(9)} has been related t o their capacity to inactivate the estrogen receptor (affinity marker prope rties).