Complement component C6 polymorphism: Novel protein-typing technique and distribution of allotypes in Germany

The genetic polymorphism of human C6 was investigated in Germany using an i mproved technique: polyacrylamide gel isoelectric focusing and subsequent d irect immunofixation with monospecific C6 antisera, Typing of C6 was perfor med on native serum samples from 1,775 unrelated persons. The gene frequenc ies in the population study were as follows: C6*A 0.6313, C6*B 0.3566 and t he rare alleles C6*R 0.0121, In total, 8 rare allotypes were analysed. The gene frequencies obtained are in good agreement with those previously publi shed. Copyright (C) 2000 S. Karger AG. Baser.