"Methyl bromide 1-year dietary study in dogs" (vol 36, pg 575, 1998)

Average human exposure resulting from consumption of methyl bromide (MB)-fu migated food has been estimated to be 0.00125 mg/kg/day. A I-yr feeding stu dy in beagle dogs was conducted as a safety study, in which the high-dose d iet was intended to yield a methyl bromide dose of at least 100 times the c alculated human dietary exposure. Diets were fumigated with IB and fed to t he dogs daily, except for weekends and holidays. MB consumption each feedin g day was calculated as a time weighted average (TWA) that accounted for th e rate of degassing From the fumigated diet and the rate of feed consumptio n during the feeding period. TWA compound consumption in the low-, mid- and high-dose groups, respectively, averaged 0.06 +/- 0.02, 0.13 +/- 0.03 and 0.28 +/- 0.08 mg/kg/day in males and 0.07 +/- 0.03, 0.12 +/- 0.03 and 0.27 +/- 0.09 mg/kg/day in females. Clinical observations, body weight and feed consumption, ophthalmology, clinical pathology, urinalysis, organ weights a nd macroscopic and microscopic pathology were comparable in control and MB- treated dogs. Under the conditions of this study. the no-observed-effect le vel (NOEL) for MB was at least 0.28 mg/kg/day, or approximately 200 times t he expected average human dietary exposure. (C) 2000 Elsevier Science Ltd. All rights reserved.