2-Ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: evaluation of the spin trapping properties

Authors
Olive, G Mercier, A Le Moigne, F Rockenbauer, A Tordo, P
Citation
G. Olive et al., 2-Ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: evaluation of the spin trapping properties, FREE RAD B, 28(3), 2000, pp. 403-408
Citations number
29
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FREE RADICAL BIOLOGY AND MEDICINE
ISSN journal
08915849 → ACNP
Volume
28
Issue
3
Year of publication
2000
Pages
403 - 408
Database
ISI
SICI code
0891-5849(20000201)28:3<403:2EOT>2.0.ZU;2-H
Abstract
The 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide (EMPO), an eas ily prepared pyrroline-N-oxide has been tested as a free radical scavenger. Spin adducts of superoxide, hydroxyl radical, and other free radicals were characterized in phosphate buffer at pH 7.0 and 5.6. At pH 7 in phosphate buffer, the EMPO/O-2(-.) spin adduct was estimated to be about five times m ore persistent than its DMPO analogue. Furthermore, its decay does not prod uce the EMPO/HO. adduct. (C) 2000 Elsevier Science Inc.