Intraperitoneal cisplatin plus epinephrine and surgical debulking for the treatment of advanced peritoneal carcinomatosis in the rat

Objective - To evaluate and compare the effects of cytoreductive surgery wi th intraperitoneal platine and epinephrine on peritoneal carcinomatosis in the rat. Material and methods - Twenty-day old peritoneal carcinomatosis was obtaine d after intraperitoneal injection of 1 x 10(6) DHD/K12/PROb cells into BDIX rats. The surgical treatment included electric fulguration of the peritone al tumors with spleen and omentum removal while intraperitoneal chemotherap y included platinum (3 mg/kg) associated with epinephrine (2 mg/kg). Results - Surgery did not increase rat survival unlike cisplatin or cisplat in/epinephrine chemotherapy. Intraperitoneal chemotherapy alone with cispla tin +/- epinephrine increased survival but did not provide cure. Surgery fo llowed by intraperitoneal cisplatin and epinephrine cured four out of five twenty-day old peritoneal carcinomatosis. Conclusion - Surgery combined with intraperitoneal cisplatin and epinephrin e could be bn efficient treatment for peritoneal carcinomatosis in man.