A new potent antifungal 'quinone methide' diterpene with a cassane skeleton from Bobgunnia madagascariensis

Authors
Sahaller, F Rahalison, L Islam, N Potterat, O Hostettmann, K Stoeckli-Evans, H Mavi, S
Citation
F. Sahaller et al., A new potent antifungal 'quinone methide' diterpene with a cassane skeleton from Bobgunnia madagascariensis, HELV CHIM A, 83(2), 2000, pp. 407-413
Citations number
21
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
HELVETICA CHIMICA ACTA
ISSN journal
0018019X → ACNP
Volume
83
Issue
2
Year of publication
2000
Pages
407 - 413
Database
ISI
SICI code
0018-019X(2000)83:2<407:ANPA'M>2.0.ZU;2-X
Abstract
A new 'quinone methide' diterpene with a cassane skeleton was isolated from the root bark of Bobgunnia madagascariensis (DESV.) J.H. KIRKBR. et WIERSE MA (Leguminosae). Its structure was established as (4bS,8aS)-4b,5,6,7,8,8a- hexahydro-4-hydroxy-2-(2-hydroxyethyl)-1,4b,8,8-tetramethylphenathrene-3,9- dione by spectroscopic methods including single-crystal X-ray analysis. Thi s compound showed strong antifungal properties towards human pathogenic fun gi, in particular the yeast Candida albicans.