Isoquinoline-based amino acid derivatives

Authors
Coppola, GM Zhang, YL Schuster, HF
Citation
Gm. Coppola et al., Isoquinoline-based amino acid derivatives, HETEROCYC C, 6(1), 2000, pp. 13-20
Citations number
9
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLIC COMMUNICATIONS
ISSN journal
07930283 → ACNP
Volume
6
Issue
1
Year of publication
2000
Pages
13 - 20
Database
ISI
SICI code
0793-0283(2000)6:1<13:IAAD>2.0.ZU;2-F
Abstract
A series of 1-aminoalkylisoquinoline-4-carboxylates (9) was synthesized by acylation of an appropriate phenethylamine derivative (4) with a phthaloyl- protected amino acid (5) followed by a Bischler-Napieralski cyclization and oxidation. N-Alkyl analogs 16 were prepared by reaction of the 1-chloromet hylisoquinoline 12 with an alkylamine.