COMPARISON OF PARATHYROID IMAGING WITH TECHNETIUM-99M-PERTECHNETATE SESTAMIBI SUBTRACTION, DOUBLE-PHASE TECHNETIUM-99M-SESTAMIBI AND TECHNETIUM-99M-SESTAMIBI SPECT/

Citation
Cc. Chen et al., COMPARISON OF PARATHYROID IMAGING WITH TECHNETIUM-99M-PERTECHNETATE SESTAMIBI SUBTRACTION, DOUBLE-PHASE TECHNETIUM-99M-SESTAMIBI AND TECHNETIUM-99M-SESTAMIBI SPECT/, The Journal of nuclear medicine, 38(6), 1997, pp. 834-839
Citations number
16
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
ISSN journal
01615505
Volume
38
Issue
6
Year of publication
1997
Pages
834 - 839
Database
ISI
SICI code
0161-5505(1997)38:6<834:COPIWT>2.0.ZU;2-E
Abstract
The ability of Tc-99m-pertechnetate/sestamibi subtraction, double-phas e Tc-99m-sestamibi and Tc-99m-sestamibi SPECT imaging to localize abno rmal parathyroid tissue was compared, Methods: Fifty-five consecutive patients had parathyroid imaging before surgery for hyperparathyroidis m, Imaging consisted of Tc-99m-pertechnetate pinhole images of the nec k followed by Tc-99m-sestamibi pinhole images of the neck and parallel -hole images of the neck and chest (early images), Within 2.5-4.0 hr l ater pinhole images of the neck, parallel-hole and SPECT images of the neck and chest were obtained (late images), Nodular fool of increased sestamibi activity were considered abnormal, Results: The sensitivity for abnormal parathyroid glands by visual comparison of early images and pertechnetate images was 72%-75%, late images and pertechnetate im ages was 73%-78% and double-phase (early and late) sestamibi images wa s 62%-65%; computer subtraction of pertechnetate from early images was 71%-74%; and SPECT imaging was 79%. The sensitivity for parathyroid a denomas was 89%-98%, while the sensitivity for hyperplastic parathyroi d glands was only 47%-58%. Conclusion: Late imaging, computer subtract ion and SPECT may not be necessary since they provided only marginal i mprovements on visual comparison of early sestamibi with pertechnetate images, Double-phase sestamibi imaging was less sensitive, so baselin e thyroid imaging with pertechnetate is recommended.